CREBBP: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CREBBP

Synonyms

CBP | KAT3A | MKHK1 | RSTS | RSTS1

Gene Description

CREBBP, CREB-binding protein, is an acetyltransferase (PMID: 30181244) that plays a key role in transcription regulation for a number of different genes involved in a variety of cellular processes including proliferation, differentiation, apoptosis, and DNA repair (PMID: 27380996, PMID: 20435671). Expression, mutations and chromosomal translocations of CREBBP have been associated with various human cancers (PMID: 23839013; PMID: 21390130; PMID: 23022987; PMID: 9290955), including glioblastoma, leukemia (PMID: 21390130, PMID: 21390126, PMID: 25423036), and small cell lung cancer (PMID: 30181244).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
1387	16	16p13.3	NM_004380	Both: Oncogene and Tumor suppressor (PMID: 30606230)

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Gene Variants 221
Category Variants 13
Molecular Profiles 220
Evidence 17
Clinical Trials 3

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CREBBP - Gene Detail

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