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| Gene Symbol | SIRPA | ||||||||||
| Synonyms | BIT | CD172A | MFR | MYD-1 | P84 | PTPNS1 | SHPS1 | SIRP | ||||||||||
| Gene Description | SIRPA, signal regulatory protein alpha, is a tyrosine-protein phosphatase non-receptor that is predominately expressed on the cell surface of macrophages and is a receptor for CD47, which upon binding inhibits phagocytosis (PMID: 29930800). Sirpa altered expression has been reported in a variety of tumor types and therapeutic disruption of binding of CD47 to the Sirpa receptor on macrophages may stimulate phagocytosis of tumor cells (PMID: 28286286, PMID: 28258703). | ||||||||||
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