Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | PARP1 | ||||||||||
| Synonyms | ADPRT | ADPRT 1 | ADPRT1 | ARTD1 | pADPRT-1 | PARP | PARP-1 | PARS | Poly-PARP | PPOL | ||||||||||
| Gene Description | PARP1, poly (ADP-ribose) polymerase 1, is an enzyme that catalyzes poly (ADP-ribosyl)ation of proteins, which initiates cellular response to DNA damage (PMID: 15743666) to repair single strand breaks through base excision repair and nucleotide excision repair (PMID: 32722408). PARP1 dysregulation has been identified in acute myeloid leukemia, breast and colorectal cancers (PMID: 25483710, PMID: 25528020, PMID: 16809031), and mutations may confer resistance to PARP inhibitors (PMID: 32722408). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
