PARP4: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

PARP4

Synonyms

Gene Description

PARP4, poly(ADP-ribose) polymerase family member 4, is an enzyme that catalyzes mono(ADP-ribosyl)ation of proteins, which initiates cellular response to DNA damage (PMID: 15273990, PMID: 10477748, PMID: 28202539, PMID: 39885134), and forms cytoplasmic ribonucleoprotein complexes that are potentially associated with intracellular transport (PMID: 13130096). Germline mutations in PARP4 have been identified in synchronous thyroid and breast cancer (PMID: 26699384).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
143	13	13q12.12	NM_006437	Unknown

Additional content available in

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Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 0

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Variant Tier Coding
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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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PARP4 - Gene Detail

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