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| Gene Symbol | CSF1R | ||||||||||
| Synonyms | BANDDOS | C-FMS | CD115 | CSF-1R | CSFR | FIM2 | FMS | GPSC | HDLS | HDLS1 | M-CSF-R | ||||||||||
| Gene Description | CSF1R, colony stimulating factor 1 receptor, is a tyrosine kinase and receptor for CSF1 and IL34, which upon ligand binding activates PI3K-AKT-mTOR, RAS-RAF-MEK-ERK and STAT signaling pathways (PMID: 22186992). CSF1R is expressed by tumor-associated macrophages to induce tumor promotion (PMID: 30065206) and therefore, a number of therapies to block Csf1r are under development (PMID: 28716061), and Csf1r activating mutations have been reported in histiocytic neoplasms (PMID: 31768065). | ||||||||||
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