Welcome to CKB CORE's new home! Please be sure to update any bookmarks you may have.
×

Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol DTX3L
Synonyms BBAP | RNF143
Gene Description DTX3L, deltex E3 ubiquitin ligase 3L, is also known as B-lymphoma and BAL-associated protein (BBAP) and plays a role in histone modification and the DNA damage response through PARP1 activation (PMID: 23230272). DTX3L overexpression has been observed in melanoma (PMID: 26033450), in glioma patients with poor prognosis (PMID: 28627634), and may play a role in chemoresistance in hematological tumors (PMID: 28653881, PMID: 25605023).
Additional content available in CKB BOOST