DTX3L - Gene Detail
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| Gene Symbol | DTX3L | ||||||||||||
| Synonyms | BBAP | RNF143 | ||||||||||||
| Gene Description | DTX3L, deltex E3 ubiquitin ligase 3L, is also known as B-lymphoma and BAL-associated protein (BBAP) and plays a role in histone modification and the DNA damage response through PARP1 activation (PMID: 23230272). DTX3L overexpression has been observed in melanoma (PMID: 26033450), in glioma patients with poor prognosis (PMID: 28627634), and may play a role in chemoresistance in hematological tumors (PMID: 28653881, PMID: 25605023). | ||||||||||||
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