CUX1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

CUX1

Synonyms

CASP | CDP | CDP/Cut | CDP1 | Clox | COY1 | CUTL1 | CUX | Cux/CDP | GDDI | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75

Gene Description

CUX1, cut like homeobox 1, is a transcription factor, that may act as a transcriptional repressor or an activator (PMID: 32547943), is required for cell motility (PMID: 22306263), and plays a role in cell cycle progression, cell proliferation, and DNA repair (PMID: 28147323). CUX1 fusions with BRAF have been observed in solid tumors (PMID: 25190083, PMID: 26314551), with FGFR1 in hematological tumors (PMID: 21330321), and with ALK in NSCLC (PMID: 30010043), and altered Cux1 expression may play a role in castrate resistant prostate cancer (PMID: 32180898).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
1523	7	7q22.1	NM_181552	Both: Oncogene and Tumor suppressor (PMID: 30606230)

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Category Variants 3
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CUX1 - Gene Detail

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