Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol KLB
Synonyms BKL
Gene Description KLB, klotho beta, is a transmembrane protein that interacts with fibroblast growth factor receptors (FGFR's) to promote high affinity Fgf binding and therefore, regulates cell metabolism and growth (PMID: 18772362, PMID: 20657013). Overexpression of KLB has been identified in bladder cancer (PMID: 27573985), hepatocellular carcinoma (PMID: 22439738, PMID: 30698907), and phosphaturic mesenchymal tumors (PMID: 31792355).
Additional content available in CKB BOOST