Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | DDX3X | ||||||||||
| Synonyms | CAP-Rf | DBX | DDX14 | DDX3 | HLP2 | MRX102 | MRXSSB | ||||||||||
| Gene Description | DDX3X, DEAD-box helicase 3 X-linked, is a member of the DEAD-box RNA helicase family and plays a role in several cellular processes including mRNA metabolism (PMID: 31906196), translation initiation, cell-cycle regulation, and cell survival (PMID: 26541825, PMID: 27180681), and functions in brain cortical development (PMID: 32135084). DDX3X mutations have been demonstrated in several tumor types, including leukemia and medulloblastoma (PMID: 26541825, PMID: 27180681), and overexpression has been observed in several solid tumors, including pancreatic ductal adenocarcinoma (PMID: 31906196), while decreased expression has been observed in other tumor types, including uveal melanoma and diffuse large B-cell lymphoma (PMID: 31906196). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
