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DUSP2 - Gene Detail

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Gene Symbol DUSP2
Synonyms PAC-1 | PAC1
Gene Description DUSP2, dual specificity phosphatase 2, dephosphorylates Erk and p38 and regulates MAPK (PMID: 16474395, PMID: 8107850) and STAT3 signaling (PMID: 26479789, PMID: 37483429), and plays a role in inflammatory response (PMID: 16474395, PMID: 26479789) and antitumor immunity (PMID: 31932812). Mutations in DUSP2 have been identified in primary mediastinal B-cell lymphoma (PMID: 38055913), large granular lymphocyte leukemia (PMID: 14680939), and diffuse large B-cell lymphoma (PMID: 36975733).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
1844 2 2q11.2 NM_004418 Unknown
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