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| Gene Symbol | DUSP4 | ||||||||||
| Synonyms | HVH2 | MKP-2 | MKP2 | TYP | ||||||||||
| Gene Description | DUSP4, dual specificity phosphatase 4, dephosphorylates ERK (PMID: 7535768) and JNK (PMID: 8626452), and plays an important role in cell survival and apoptosis (PMID: 16778175, PMID: 21317287) and immune response (PMID: 21085614, PMID: 22434910). Overexpression of Dusp4 has been observed in breast cancer (PMID: 12618338) and colorectal cancer (PMID: 23749251), and decreased Dusp4 expression has been identified in EGFR-mutant lung cancer (PMID: 19525976) and diffuse large B cell lymphoma (PMID: 25847947). | ||||||||||
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