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Gene Symbol ELF3
Synonyms EPR-1 | ERT | ESE-1 | ESX
Gene Description ELF3, E74 like ETS transcription factor 3, is a transcriptional activator involved in inflammation (PMID: 22157719), cell differentiation (PMID: 29523781), and cell cycle progression (PMID: 29050229). ELF3 overexpression has been implicated in ERBB2 (HER2) positive breast cancer progression (PMID: 29050229, PMID: 29187433) and hepatocellular carcinoma (PMID: 29523781), while decreased expression has been correlated with reduced survival in ovarian cancer (PMID: 28199976), and ELF3 amplification and hypomethylation in lung adenocarcinoma may be oncogenic (PMID: 31780666).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
1999 1 1q32.1 NM_004433 Tumor suppressor (PMID: 30606230)
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