Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol EP300
Synonyms KAT3B | MKHK2 | p300 | RSTS2
Gene Description EP300, E1A binding protein p300, is a lysine acetyltransferase that regulates gene transcription through acetylation of histones and other proteins, as well as acting as a transcriptional co-activator in the regulation of the cell cycle (PMID: 27881443). EP300 is frequently mutated in various tumor types (PMID: 25111821, PMID: 24622842), including skin squamous cell carcinoma, marginal zone B-cell lymphoma (PMID: 27881443), and bladder cancer (PMID: 32012118), and may be oncogenic in esophageal squamous carcinoma (PMID: 31632486).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2033 22 22q13.2 NM_001429 Tumor suppressor (PMID: 30606230)
Additional content available in CKB BOOST