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ERCC3 - Gene Detail

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Gene Symbol ERCC3
Synonyms BTF2 | GTF2H | RAD25 | Ssl2 | TFIIH | TTD2 | XPB
Gene Description ERCC3, ERCC excision repair 3, TFIIH core complex helicase subunit, is an ATP-dependent 5’-3’ DNA helicase that plays a role in nucleotide excision repair and RNA transcription (PMID: 8157004). An ERCC3 nonsense mutation has been associated with breast cancer risk (PMID: 27655433) and ERCC3 mRNA expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PMID: 27384421).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2071 2 2q14.3 NM_000122 Tumor suppressor (PMID: 30606230)
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