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Gene Symbol FANCA
Synonyms FA | FA-H | FA1 | FAA | FACA | FAH | FANCH
Gene Description FANCA, FA complementation group A, is a member of the Fanconi anemia (FA) nuclear complex, which plays a role in DNA repair (PMID: 11673408, PMID: 12509764, PMID: 30057198), and is required for nuclear localization of the FA core complex (PMID: 32002546). Germline FANCA mutations are associated with Fanconi anemia, which involves predisposition to various cancers (PMID: 12509764, PMID: 32235514, PMID: 29098742), including acute myeloid leukemia (PMID: 25455269) and ovarian high-grade serous carcinoma (PMID: 32019284), and loss of FANCA has been reported in prostate cancer (PMID: 31931827).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2175 16 16q24.3 NM_000135 Tumor suppressor (PMID: 30606230)
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