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Gene Symbol FANCC
Synonyms FA3 | FAC | FACC
Gene Description FANCC, FA complementation group C, is a member of the Fanconi anemia core complex, which plays a role in DNA repair (PMID: 22675617, PMID: 27145721). Germline FANCC mutations are associated with Fanconi anemia, which involves predisposition to various cancers (PMID: 32235514), including pancreatic cancer (PMID: 15695377, PMID: 32113160) and colorectal cancer (PMID: 27165003), although some FANCC truncating mutations do not increase breast cancer risk (PMID: 31467304).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2176 9 9q22.32 NM_000136 Tumor suppressor (PMID: 30606230)
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