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Gene Symbol FANCE
Synonyms FACE | FAE
Gene Description FANCE, FA complementation group E, is a member of the Fanconi anemia core complex, which plays a role in DNA repair (PMID: 27145721, PMID: 17308347). Germline FANCE mutations are associated with Fanconi anemia, which involves predisposition to various cancers (PMID: 25237197, PMID: 32235514), including colorectal cancer (PMID: 27165003), sarcoma (PMID: 28878254), and head and neck squamous cell carcinoma (PMID: 28678401).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2178 6 6p21.31 NM_021922 Tumor suppressor (PMID: 30606230)
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