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Gene Symbol FAT1
Synonyms CDHF7 | CDHR8 | FAT | hFat1 | ME5
Gene Description FAT1, FAT atypical cadherin 1, is a transmembrane atypical cadherin that regulates cell growth via inhibition of the Yap1 pathway, and is involved in cell migration and invasion (PMID: 23076869, PMID: 29565465). FAT1 homozygous deletions have been identified in glioblastoma, astrocytoma and oral cancers (PMID: 23076869, PMID: 23354438), and mutations have been observed in several tumor types including glioblastoma, head and neck squamous cell carcinoma, colorectal, and esophageal cancer (PMID: 23354438, PMID: 23076869, PMID: 29565465), and T-cell acute lymphoblastic leukemia (PMID: 24972153).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2195 4 4q35.2 NM_005245 Tumor suppressor (PMID: 30606230)
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