GPC2 - Gene Detail
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| Gene Symbol | GPC2 | ||||||||||||
| Synonyms | |||||||||||||
| Gene Description | GPC2, glypican 2, is a cell-surface heparan sulfate proteoglycan that plays a role in neural development (PMID: 8294498) and neurite outgrowth (PMID: 12084985, PMID: 27671118), and is involved in regulation of the Wnt signaling pathway (PMID: 40416340). GPC2 overexpression has been observed in various tumor types (PMID: 35345673), including neuroblastoma (PMID: 28898695), pediatric brain tumors (PMID: 36167467) and acute lymphocytic leukemia (PMID: 34337560), retinoblastoma (PMID: 38864848), prostate cancer (PMID: 39014225), and small cell lung cancer (PMID: 34337560). | ||||||||||||
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