GPC4 - Gene Detail
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| Gene Symbol | GPC4 | ||||||||||||
| Synonyms | K-glypican | KPTS | ||||||||||||
| Gene Description | GPC4, glypican 4, encodes a heparan sulfate proteoglycan (PMID: 15112050) that regulates Wnt (PMID: 22302992) and insulin receptor (PMID: 22751693) signaling, and plays a role in stem cell self-renewal (PMID: 22761013), cell differentiation (PMID: 25968312), and neural synapse formation (PMID: 25624497, PMID: 29024665). Differential expression of GPC4 has been observed in various tumor types (PMID: 38612755), including increased GPC4 expression in colorectal cancer (PMID: 31484922), and decreased GPC4 expression in metastatic breast cancer (PMID: 32199612). | ||||||||||||
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