FGR: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

FGR

Synonyms

Gene Description

FGR, FGR proto-oncogene, Src family tyrosine kinase, is a non-receptor tyrosine kinase that is a member of the Src gene family and plays a role in the control of integrin-mediated signal transduction, affecting the actin cytoskeletal structure and cell migration (PMID: 10547366). An FGR-WASF2 fusion has been identified in melanoma, ovarian cancer, and lung squamous cell carcinoma (PMID: 25204415) while a fusion of FYB-FGR was found in lymphoma (Journal of Clinical Oncology 35, no. 15_suppl), and increased expression of FGR has been observed in B-cell lymphomas and may be associated with resistance to HDAC inhibitors (PMID: 27324824).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
2268	1	1p35.3	NM_005248	Unknown

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Gene Variants 5
Category Variants 1
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FGR - Gene Detail

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