Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | IKZF3 | ||||||||||
| Synonyms | AIO | AIOLOS | IMD84 | ZNFN1A3 | ||||||||||
| Gene Description | IKZF3, IKAROS family zinc finger 3, encodes the transcription factor Aiolos, which is involved in regulating gene expression and chromatin remodeling to control lymphocyte proliferation, differentiation, maturation, and survival (PMID: 10369681, PMID: 11997672, PMID: 21477865). IKZF3 mutations have been identified in chronic myeloid leukemia (PMID: 24212482), and overexpression of IKZF3 has been observed in chronic lymphocytic leukemia (PMID: 18184862, PMID: 19016725), multiple myeloma (PMID: 26823144), and lung cancer (PMID: 27308319). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
