Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | DIS3 | ||||||||||
| Synonyms | 2810028N01Rik | dis3p | EXOSC11 | KIAA1008 | RRP44 | ||||||||||
| Gene Description | DIS3, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, encodes a catalytic subunit of the endosome, which is involved in the processing of small RNAs, regulation of gene expression, and mRNA quality control (PMID: 26193331). DIS3 mutations have been identified in multiple myeloma (PMID: 25521164), and altered expression has been identified in multiple cancers (PMID: 26193331), including overexpression in colorectal carcinoma (PMID: 24478024), and decreased expression in chronic lymphocytic leukemia (PMID: 17047154). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
