KLRK1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

KLRK1

Synonyms

CD314 | D12S2489E | KLR | NKG2-D | NKG2D

Gene Description

KLRK1, killer cell lectin like receptor K1, encodes a transmembrane protein that upon ligand binding activates NK cells and T lymphocytes (PMID: 15894612, PMID: 16380817, PMID: 12150888), and plays a role in immune surveillance (PMID: 24615398), adaptive and innate immune responses (PMID: 14523385, PMID: 20536570), and immune cell development (PMID: 21898152, PMID: 30224819). Decreased expression of KLRK1 on NK cells has been identified in chronic lymphocytic leukemia (PMID: 25286418), gastric cancer (PMID: 21626292), and colorectal cancer (PMID: 22200673).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
22914	12	12p13.2	NM_007360	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 0

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

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KLRK1 - Gene Detail

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