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KLRK1 - Gene Detail

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Gene Symbol KLRK1
Synonyms CD314 | D12S2489E | KLR | NKG2-D | NKG2D
Gene Description KLRK1, killer cell lectin like receptor K1, encodes a transmembrane protein that upon ligand binding activates NK cells and T lymphocytes (PMID: 15894612, PMID: 16380817, PMID: 12150888), and plays a role in immune surveillance (PMID: 24615398), adaptive and innate immune responses (PMID: 14523385, PMID: 20536570), and immune cell development (PMID: 21898152, PMID: 30224819). Decreased expression of KLRK1 on NK cells has been identified in chronic lymphocytic leukemia (PMID: 25286418), gastric cancer (PMID: 21626292), and colorectal cancer (PMID: 22200673).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
22914 12 12p13.2 NM_007360 Unknown
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