NT5C2: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

NT5C2

Synonyms

cN-II | GMP | NT5B | PNT5 | SPG45 | SPG65

Gene Description

NT5C2, 5'-nucleotidase, cytosolic II, functions in 5' dephosphorylation of nucleotides including inosine monophosphate (IMP), guanosine monophosphate (GMP), and xanthine monophosphate (XMP), which are then exported from the cell, serving to regulate cellular purine pools (PMID: 29990496, PMID: 31358663, PMID: 30910786). NT5C2 activating mutations are associated with resistance to thiopurine chemotherapy, and are frequent in relapsed acute lymphoblastic leukemia (PMID: 29990496, PMID: 31358663, PMID: 30910786).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
22978	10	10q24.32-q24.33	NM_012229	oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 17
Category Variants 2
Molecular Profiles 17
Evidence 0
Clinical Trials 0

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NT5C2 - Gene Detail

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