Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol PDS5B
Synonyms APRIN | AS3 | CG008
Gene Description PDS5B, PDS5 cohesin associated factor B, is a member of the cohesin complex, which plays a key role in centromere and sister chromatid cohesion, and regulates chromosome segregation, homologous recombination, and differentiation of stem cells (PMID: 15855230, PMID: 20383194, PMID: 24141881, PMID: 24854081, PMID: 27924011). Mutations in PDS5B and loss of Pds5b expression have been demonstrated in gastric and colorectal cancer with microsatellite instability (PMID: 23850494).
Additional content available in CKB BOOST