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Gene Symbol FOXO1
Synonyms FKH1 | FKHR | FOXO1A
Gene Description FOXO1, forkhead box O1, encodes for a protein belonging to the family of forkhead box O transcription factors, which plays a role in multiple cellular processes including cell cycle arrest, apoptosis, and prevention of reactive oxygen species (PMID: 18715783). FOXO1 fusions are frequently observed in alveolar rhabdomyosarcoma (PMID: 24334454), including FOXO1-FGFR1 (PMID: 21666686), PAX3-FOXO1 (PMID: 24334454), and PAX7-FOXO1 (PMID: 12865925, PMID: 8187070).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2308 13 13q14.11 NM_002015 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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