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Gene Symbol FOXO3
Synonyms AF6q21 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A
Gene Description FOXO3, forkhead box O3, encodes for a protein belonging to the Forkhead box O family of transcription factors, which plays a role in multiple cellular functions such as cell proliferation, apoptosis, autophagy, and metabolism (PMID: 24864265). Overexpression of FOXO3 has been associated with worse prognosis in several tumor types including neuroblastoma, gastric, hepatocarcinoma (PMID: 32256814), renal cell carcinoma, and breast cancer (PMID: 25678856).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2309 6 6q21 NM_001455 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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