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Gene Symbol ARHGAP26
Synonyms GRAF | GRAF1 | OPHN1L | OPHN1L1
Gene Description ARHGAP26, Rho GTPase activating protein 26, encodes for a protein that negatively regulates the Rho family by converting RhoA and Cdc42 to their inactive forms via GDP binding, and is necessary for muscle development (PMID: 24067935). A CLDN18-ARHGAP26 fusion has been identified in gastric cancer, primarily including those of the diffuse-type (PMID: 30034621).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
23092 5 5q31.3 NM_015071 Tumor suppressor (PMID: 30606230)
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