FLI1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

FLI1

Synonyms

BDPLT21 | EWSR2 | FLI-1 | SIC-1

Gene Description

FLI1, Fli-1 proto-oncogene, ETS transcription factor, is a member of the Ets transcription family and is involved in embryogenesis and hematopoiesis (PMID: 11175359), and regulates a number of genes involved in the the cell cycle (PMID: 31846072). The fusion protein EWSR1-FLI1 can result in malignant transformation and is commonly found in Ewing sarcoma (PMID: 19417137, PMID: 31649319) and expression in breast cancer was observed to be associated with the immune infiltrate level in breast cancer (PMID: 32249526).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
2313	11	11q24.3	NM_002017	Oncogene (PMID: 30606230)

Additional content available in

CKB BOOST

Gene Variants 4
Category Variants 2
Molecular Profiles 2
Evidence 17
Clinical Trials 1

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

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Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

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System Integration

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The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

FLI1 - Gene Detail

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