FLI1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

FLI1

Synonyms

BDPLT21 | EWSR2 | FLI-1 | SIC-1

Gene Description

FLI1, Fli-1 proto-oncogene, ETS transcription factor, is a member of the Ets transcription family and is involved in embryogenesis and hematopoiesis (PMID: 11175359), and regulates a number of genes involved in the the cell cycle (PMID: 31846072). The fusion protein EWSR1-FLI1 can result in malignant transformation and is commonly found in Ewing sarcoma (PMID: 19417137, PMID: 31649319) and expression in breast cancer was observed to be associated with the immune infiltrate level in breast cancer (PMID: 32249526).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
2313	11	11q24.3	NM_002017	Oncogene (PMID: 30606230)

Additional content available in

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Gene Variants 4
Category Variants 2
Molecular Profiles 2
Evidence 17
Clinical Trials 1

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Variant Tier Coding
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FLI1 - Gene Detail

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