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LARP4B - Gene Detail

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Gene Symbol LARP4B
Synonyms KIAA0217 | LARP5
Gene Description LARP4B, La ribonucleoprotein 4B, encodes a member of the La-related protein (LARP) family of RNA binding proteins, and plays a role in promoting translation by binding to the 3' UTRs of mRNA targets, and interacting with Pabpc1 and Rack1 (PMID: 26001795, PMID: 20573744), and promotes inhibition of cell growth (PMID: 26933087). LARP4B overexpression has been identified in liver cancer (PMID: 31772683) while decreased expression has been observed in glioma (PMID: 26933087) and KMT2A (MLL)-rearranged acute myeloid leukemia (PMID: 25534202).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
23185 10 10p15.3 NM_015155 Tumor suppressor (PMID: 30606230)
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