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Gene Symbol | FLT3 | ||||||||||
Synonyms | CD135 | FLK-2 | FLK2 | STK1 | ||||||||||
Gene Description | FLT3, fms related receptor tyrosine kinase 3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385, PMID: 32241850). | ||||||||||
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