POFUT1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

POFUT1

Synonyms

Gene Description

POFUT1, protein O-fucosyltransferase 1, encodes a glycosyltransferase that catalyzes O-linked fucosylation of EGF-like repeats in receptor proteins and plays a role in regulating Notch signaling (PMID: 11524432, PMID: 18347015, PMID: 28729422). POFUT1 amplification has been observed in colorectal cancer and colorectal adenoma (PMID: 30380753, PMID: 31411736), and POFUT1 mutations have been demonstrated in colorectal cancer (PMID: 32486426).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
23509	20	20q11.21	NM_015352	Unknown

Additional content available in

CKB BOOST

Gene Variants 9
Category Variants 2
Molecular Profiles 9
Evidence 0
Clinical Trials 0

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Variant Tier Coding
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POFUT1 - Gene Detail

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