FPGS - Gene Detail
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| Gene Symbol | FPGS | ||||||||||||
| Synonyms | |||||||||||||
| Gene Description | FPGS, folylpolyglutamate synthase, is an enzyme that is essential to maintaining intracellular folate homeostasis by forming polyglutamated folates from folate monoglutamates (PMID: 25164808, PMID: 36721160), and plays a role in methotrexate sensitivity (PMID: 8408021, PMID: 26547381). Mutations in FPGS have been identified in relapsed pediatric acute lymphoblastic leukemia (PMID: 32694622), alternative splicing of FPGS has been observed in adult and pediatric acute lymphoblastic leukemia (PMID: 19131550, PMID: 26547381, PMID: 27036162), and increased expression of Fpgs has been observed in colon cancer (PMID: 39998667). | ||||||||||||
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