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CBLC - Gene Detail

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Gene Symbol CBLC
Synonyms CBL-3 | CBL-SL | RNF57
Gene Description CBLC, Cbl proto-oncogene C, is an ubiquitin ligase that targets activated receptor kinases for degradation (PMID: 10362357). Overexpression of Cblc has been observed in non-small cell lung cancer (PMID: 29945960), mutations have been identified in myeloproliferative neoplasms (PMID: 22315494), and Cblc may modulate response to PARP inhibitors (PMID: 25883215).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
23624 19 19q13.32 NM_012116 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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