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Gene Symbol | ABL1 | ||||||||||
Synonyms | ABL | BCR-ABL | bcr/abl | c-ABL | c-ABL1 | CHDSKM | JTK7 | p150 | v-abl | ||||||||||
Gene Description | ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, plays a role in regulation of cell growth through ERK5, Rac/JNK, and Stat1/3 pathways (PMID: 10373409). Fusion proteins of BCR-ABL1 resulting in constitutive kinase activity have been reported in various cancers (PMID: 18851712, PMID: 30125955) and a number of Abl1 mutations in the context of BCR-ABL1 have been demonstrated to confer drug resistance (PMID: 24456693). | ||||||||||
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Variant | Impact | Protein Effect | Variant Description | Associated With Drug Resistance |
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Variant | Impact | Protein Effect | Variant Description | Associated With Drug Resistance |
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Molecular Profile | Protein Effect | Treatment Approaches |
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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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