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Gene Symbol | ABL1 | ||||||||||
Synonyms | ABL | BCR-ABL | bcr/abl | c-ABL | c-ABL1 | CHDSKM | JTK7 | p150 | v-abl | ||||||||||
Gene Description | ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, plays a role in regulation of cell growth through ERK5, Rac/JNK, and Stat1/3 pathways (PMID: 10373409). Fusion proteins of BCR-ABL1 resulting in constitutive kinase activity have been reported in various cancers (PMID: 18851712, PMID: 30125955) and a number of Abl1 mutations in the context of BCR-ABL1 have been demonstrated to confer drug resistance (PMID: 24456693). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ABL1 A287V | unknown | |
ABL1 A337T | gain of function | |
ABL1 A337V | gain of function | |
ABL1 A344P | gain of function - predicted | |
ABL1 A356T | gain of function | |
ABL1 A380T | unknown | |
ABL1 A397P | unknown | |
ABL1 act mut | gain of function | |
ABL1 amp | no effect | |
ABL1 C330G | unknown | |
ABL1 C475W | unknown | |
ABL1 D276G | gain of function - predicted | |
ABL1 D363G | unknown | |
ABL1 E1085K | unknown | |
ABL1 E255K | unknown | |
ABL1 E255V | unknown | |
ABL1 E275D | unknown | |
ABL1 E279K | unknown | |
ABL1 E279V | unknown | |
ABL1 E279W | unknown | |
ABL1 E281K | unknown | |
ABL1 E282D | unknown | |
ABL1 E292L | unknown | |
ABL1 E308* | loss of function - predicted | |
ABL1 E355A | unknown | |
ABL1 E355G | unknown | |
ABL1 E450G | unknown | |
ABL1 E453K | unknown | |
ABL1 E459K | unknown | |
ABL1 E507G | unknown | |
ABL1 F311I | unknown | |
ABL1 F311L | unknown | |
ABL1 F317C | unknown | |
ABL1 F317I | unknown | |
ABL1 F317L | unknown | |
ABL1 F317R | unknown | |
ABL1 F317V | unknown | |
ABL1 F359C | unknown | |
ABL1 F359I | unknown | |
ABL1 F359V | unknown | |
ABL1 F401V | unknown | |
ABL1 F486S | unknown | |
ABL1 fusion | unknown | |
ABL1 G250E | unknown | |
ABL1 G250H | unknown | |
ABL1 G250R | unknown | |
ABL1 G250R ABL1 G251D | ||
ABL1 G250W | unknown | |
ABL1 G251D | unknown | |
ABL1 G251E | unknown | |
ABL1 G321L | gain of function - predicted | |
ABL1 G463S | unknown | |
ABL1 H295dup | unknown | |
ABL1 H396P | unknown | |
ABL1 H396R | unknown | |
ABL1 I242M | unknown | |
ABL1 I432M | unknown | |
ABL1 I502L | unknown | |
ABL1 inact mut | loss of function | |
ABL1 K262N | unknown | |
ABL1 K262T | unknown | |
ABL1 K294E | unknown | |
ABL1 K357dup | unknown | |
ABL1 K596* | loss of function - predicted | |
ABL1 K609del | unknown | |
ABL1 L248R | unknown | |
ABL1 L248V | unknown | |
ABL1 L298V | unknown | |
ABL1 L302H | unknown | |
ABL1 L384M | unknown | |
ABL1 L387M | unknown | |
ABL1 M237R | unknown | |
ABL1 M237V | unknown | |
ABL1 M244V | unknown | |
ABL1 M343T | unknown | |
ABL1 M351T | loss of function - predicted | |
ABL1 M388L | unknown | |
ABL1 M437I | unknown | |
ABL1 mutant | unknown | |
ABL1 N368S | unknown | |
ABL1 over exp | no effect | |
ABL1 P223S | unknown | |
ABL1 P230E | unknown | |
ABL1 P309fs | loss of function - predicted | |
ABL1 P310L | unknown | |
ABL1 P465S | gain of function | |
ABL1 P918S | unknown | |
ABL1 P980L | unknown | |
ABL1 Q252H | unknown | |
ABL1 Q346L | unknown | |
ABL1 R239C | unknown | |
ABL1 R239G | unknown | |
ABL1 R332W | gain of function | |
ABL1 T315I ABL1 R332W | ||
ABL1 R362fs | loss of function - predicted | |
ABL1 R362T | unknown | |
ABL1 R386M | unknown | |
ABL1 R516L | unknown | |
ABL1 R577* | loss of function - predicted | |
ABL1 R639* | loss of function - predicted | |
ABL1 rearrange | unknown | ABL Inhibitor (pan) |
ABL1 S417Y | unknown | |
ABL1 S972L | unknown | |
ABL1 T277I | unknown | |
ABL1 T315A | unknown | |
ABL1 T315C | unknown | |
ABL1 T315D | unknown | |
ABL1 T315E | unknown | |
ABL1 T315F | unknown | |
ABL1 T315G | unknown | |
ABL1 T315H | unknown | |
ABL1 T315I | unknown | |
ABL1 T315K | unknown | |
ABL1 T315L | unknown | |
ABL1 T315M | unknown | |
ABL1 T315N | unknown | |
ABL1 T315P | unknown | |
ABL1 T315Q | unknown | |
ABL1 T315R | unknown | |
ABL1 T315S | unknown | |
ABL1 T315V | unknown | |
ABL1 T315W | unknown | |
ABL1 T315Y | unknown | |
ABL1 V289F | unknown | |
ABL1 V299L | unknown | |
ABL1 V338A | unknown | |
ABL1 V379I | unknown | |
ABL1 V422I | unknown | |
ABL1 V468F | gain of function | |
ABL1 wild-type | no effect | |
ABL1 Y226C | gain of function | |
ABL1 Y245C | gain of function | |
ABL1 Y253F | unknown | |
ABL1 Y253H | unknown | |
ABL1 Y440C | unknown | |
ABL1 Y456C | unknown |