G6PD - Gene Detail
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| Gene Symbol | G6PD | ||||||||||||
| Synonyms | CNSHA1 | G6PD1 | ||||||||||||
| Gene Description | G6PD, glucose-6-phosphate dehydrogenase, catalyzes the rate-limiting step in the pentose phosphate pathway to convert glucose-6-phosphate (G6P) to 6-phosphogluconolactone (6PGL) (PMID: 38139067) and reduce NADP to NADPH, and is important in redox homeostasis (PMID: 35216131, PMID: 38139067) and macromolecule biosynthesis (PMID: 38139067), and plays a role in cell growth (PMID: 9553122), migration, and differentiation (PMID: 35216131), and innate and adaptive immunity (PMID: 38938571). Altered G6PD expression has been observed in several tumor types (PMID: 37335542), including increased expression in triple-negative breast cancer (PMID: 37237244), lung adenocarcinoma (PMID: 39165939), and hepatocellular carcinoma (PMID: 29471502). | ||||||||||||
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