Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Gene Symbol | GAB1 | ||||||||||
| Synonyms | DFNB26 | ||||||||||
| Gene Description | GAB1, GRB2-associated-binding protein 1, is an adaptor protein that mediates signal transduction from tyrosine kinase receptors, including Egfr, Met, and Src to regulate cell proliferation and migration (PMID: 22751113). Amplification, overexpression, and somatic mutations have been observed in Bcr-Abl-positive adult acute lymphoblastic leukemia (PMID: 17312329), medulloblastoma (PMID: 21267586), breast cancer (PMID: 16959974), and colorectal cancer (PMID: 16959974). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
