Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene Symbol GLI2
Synonyms CJS | HPE9 | PHS2 | THP1 | THP2
Gene Description GLI2, GLI family zinc finger 2, is a transcription factor acting in the Sonic Hedgehog signaling pathway of developmental regulation and is also induced by TGF-beta independently of hedgehog (PMID: 21862631). Crosstalk from hedgehog and TGF-beta may create a cycle that amplifies GLI2-dependent metastasis (PMID: 21862631) and a FHL2-GLI2 fusion has been reported in sclerosing stromal tumors of the ovary (PMID: 31896750).
Additional content available in CKB BOOST