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Gene Symbol GNAS
Synonyms AHO | AIMAH1 | C20orf45 | GNAS1 | GPSA | GSA | GSP | NESP | PITA3 | POH | SCG6 | SgVI
Gene Description GNAS, GNAS complex locus, is a GTPase that is activated upon ligand binding of a G-protein coupled receptor, and is involved in mediating hormone response (PMID: 23640210, PMID: 25851935). Hotspot mutations impair Gnas GTPase activity, resulting in constitutive pathway activation and are common in a variety of tumor types (PMID: 23640210).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
2778 20 20q13.32 NM_080425 Oncogene (PMID: 30606230)
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