ANPEP: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

ANPEP

Synonyms

AP-M | AP-N | APN | CD13 | GP150 | hAPN | LAP1 | P150 | PEPN

Gene Description

ANPEP, alanyl aminopeptidase, membrane, is a membrane-bound metalloproteinase that preferentially cleaves neutral amino acids of biologically active peptides (PMID: 18603472), and has non-enzymatic functions in diverse biological processes including phagocytosis (PMID: 24063007), cell polarity (PMID: 34349123), integrin recycling and cell migration (PMID: 31040262), angiogenesis (PMID: 11157481), and viral infection (PMID: 1350662). Increased expression of ANPEP has been observed in pancreatic cancer (PMID: 27788483), non-small cell lung cancer (PMID: 16361553), and hepatocellular carcinoma (PMID: 29145632).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
290	15	15q26.1	NM_001150	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 0
Clinical Trials 1

KEY FEATURES

CKB CORE^TM

CKB BOOST^TM

CKB FLEX^TM

Access 50 genes & related content

Access 2000+ genes & related content

Scalable & flexible content integration for 2000+ genes

Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

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ANPEP - Gene Detail

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