CD274 - Gene Detail

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Gene Symbol CD274
Synonyms ADMIO5 | B7-H | B7H1 | hPD-L1 | PD-L1 | PDCD1L1 | PDCD1LG1 | PDL1
Gene Description CD274 (PD-L1), CD274 molecule, is also known as PD-L1 and is an immunomodulatory ligand, which once bound to its receptor, PD-1 (PDCD1), results in inhibition of T-cell activation (PMID: 24551119) and therefore, is a T cell inhibitory checkpoint protein (PMID: 31940272). CD274 (PD-L1) overexpression has been observed across multiple tumor types and has been associated with CD274 (PD-L1) amplification, specifically in Hodgkin's lymphoma (PMID: 20628145), and CD274 (PD-L1) expression may be indicative of response to immune checkpoint inhibitors in select cancers (PMID: 32269612, PMID: 29097600).
NCBI Gene ID Chromosome Map Location Canonical Transcript MANE Select Gene Role
29126 9 9p24.1 NM_014143 Y Tumor suppressor (PMID: 30606230)

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Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Variant Impact Protein Effect Variant Description Associated With Drug Resistance
Molecular Profile Protein Effect Treatment Approaches
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries