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Gene Symbol A1CF
Synonyms ACF | ACF64 | ACF65 | APOBEC1CF | ASP
Gene Description A1CF, APOBEC1 complementation factor, is an RNA binding protein and part of a complex which edits the mRNA of apolipoprotein B (PMID: 11871661, PMID: 31881249). Deletion of an eight amino acid motif in the nuclear localization domain of A1cf has been demonstrated to promote breast cancer proliferation in culture (PMID: 27231908), decreased expression of A1cf increased apoptosis of breast cancer cells in culture (PMID: 28639893), and in Wilms tumor cell models, overexpression of A1cf decreased apoptosis (PMID: 30825095).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
29974 10 10q11.23 NM_138932 Oncogene (PMID: 30606230)
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