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Gene Symbol NRG1
Synonyms ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | MST131 | MSTP131 | NDF | NRG1-IT2 | SMDF
Gene Description NRG1, neuregulin 1, encodes for a ligand that can bind to Erbb3 (Her3) and Erbb4, which upon binding forms dimers with other ERBB (HER) family receptors, which may result in activation of downstream signaling pathways (PMID: 10880430). NRG1 forms fusions with multiple gene partners (PMID: 30988082) and have been identified in a variety of tumor types, including lung cancer (PMID: 25501131, PMID: 31382039) and pancreatic cancer (PMID: 31068372).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
3084 8 8p12 NM_013964 Tumor suppressor (PMID: 30606230)
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