NR4A1: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

NR4A1

Synonyms

GFRP1 | HMR | N10 | NAK-1 | NGFIB | NP10 | NUR77 | TR3

Gene Description

NR4A1, nuclear receptor subfamily 4 group A member 1, is an orphan nuclear receptor that functions as transcription factor to regulate genes involved in several cellular processes including cell migration, metabolism, and survival, and also binds to Bcl-2 to induce apoptosis (PMID: 25555471, PMID: 25376494, PMID: 30272297). Overexpression of Nr4a1 has been identified in several tumor types including rhabdomyosarcoma (PMID: 27144436), breast cancer (PMID: 24584437), and colorectal cancer (PMID: 25064356).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
3164	12	12q13.13	NM_002135	Unknown

Additional content available in

CKB BOOST

Gene Variants 2
Category Variants 0
Molecular Profiles 2
Evidence 3
Clinical Trials 0

KEY FEATURES

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Access 50 genes & related content

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Genes

(50 Genes)

(2000+ Genes)

Gene Variants

Therapies

Limited

Global Drug Approvals

Drug Classes

Limited

Clinical Trials

Limited

Efficacy Evidence

Variant Tier Coding
(AMP/CAP/ASCO)

Advanced Search Capability

System Integration

More about our plans

The public access version, CKB CORE™, encompasses 50 cancer-related genes, and every quarter, a select group of genes are exchanged, focusing on a specific theme. Users can search CKB CORE™ via gene and gene variants. The web-based, subscription version, CKB BOOST™, includes more than 2000 cancer-related genes and is designed to interrogate the knowledgebase for specific data attributes while enabling a robust browse-like feature when the desired content is unknown.

Downloadable data from CKB is available using the FLEX version. CKB FLEX delivers CKB content as a flat file or JSON, enabling CKB data integration.

NR4A1 - Gene Detail

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