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Gene Symbol TLX1
Synonyms HOX11 | TCL3
Gene Description TLX1, T cell leukemia homeobox 1, is a homeobox-containing transcription factor that inhibits hematopoietic differentiation (PMID: 17213805, PMID: 17555447) and is important in spleen development (PMID: 7555717, PMID: 27214556). TLX1 rearrangements and overexpression are associated with T-cell acute lymphoblastic leukemia (PMID: 21705452, PMID: 28671688, PMID: 35385357), and a fusion between TCF3 and TLX1 has been identified in B-cell precursor acute lymphoblastic leukemia (PMID: 37058324).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
3195 10 10q24.31 NM_005521 Oncogene (PMID: 30606230)
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