BIRC3: Gene Detail - Cancer Knowledgebase (CKB)

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Gene Symbol

BIRC3

Synonyms

Gene Description

BIRC3, baculoviral IAP repeat containing 3, is a member of the inhibitors of apoptotic protein (IAP) family that regulates apoptosis and other cellular processes through ubiquitination of targeting proteins (PMID: 23790005). BIRC3 mutations are frequently identified in hematological cancers (PMID: 17692804, PMID: 21881048, PMID: 24145436), including chronic lymphocytic leukemia (PMID: 31371416).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
330	11	11q22.2	NM_001165	Both: Oncogene and Tumor suppressor (PMID: 30606230)

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Category Variants 10
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Clinical Trials 1

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BIRC3 - Gene Detail

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