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Gene Symbol BIRC3
Synonyms AIP1 | API2 | c-IAP2 | CIAP2 | HAIP1 | HIAP1 | IAP-1 | MALT2 | MIHC | RNF49
Gene Description BIRC3, baculoviral IAP repeat containing 3, is a member of the inhibitors of apoptotic protein (IAP) family that regulates apoptosis and other cellular processes through ubiquitination of targeting proteins (PMID: 23790005). BIRC3 mutations are frequently identified in hematological cancers (PMID: 17692804, PMID: 21881048, PMID: 24145436), including chronic lymphocytic leukemia (PMID: 31371416).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
330 11 11q22.2 NM_001165 Both: Oncogene and Tumor suppressor (PMID: 30606230)
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