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Gene Symbol RSPO2
Synonyms CRISTIN2 | HHRRD | TETAMS2
Gene Description RSPO2, R-spondin 2, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling due to its furin repeat domains (PMID: 24980904). RSPO2 fusions with EIF3E (PMID: 22895193), PRR15L (PMID: 31209633), and PIEZO1 (PMID: 30916365) have been identified in colorectal traditional serrated adenomas.
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
340419 8 8q23.1 NM_178565 Tumor suppressor (PMID: 30606230)
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