IDH1 - Gene Detail

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Gene Symbol IDH1
Synonyms HEL-216 | HEL-S-26 | IDCD | IDH | IDP | IDPC | PICD
Gene Description IDH1, isocitrate dehydrogenase (NADP(+)) 1, is an enzyme that catalyzes the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and is involved in the tricarboxylic acid cycle (PMID: 23999441, PMID: 28711227). Mutations in IDH1 are associated with aberrant conversion of alpha-KG to 2-HG, which is an oncogenic metabolite, and are recurrent in acute myeloid leukemia (PMID: 23999441) and glioma (PMID: 28711227, PMID: 32186930).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
3417 2 2q34 NM_005896 Oncogene (PMID: 30606230)

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